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Leveraging clinical genomics for candidate neoantigen discovery
Eliezer M. Van Allen
Dana-Farber Cancer Inst., Boston, MA, United States
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Navigating the known and unknown challenges in the development of a selective NTRK inhibitor: The larotrectinib story
Keith T Flaherty
Massachusetts General Hosp. Cancer Ctr., Boston, MA, United States
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Job's dilemma for the genome: Why bad things happen to good chromosomes
David Pellman
Dana-Farber Cancer Institute, Boston, MA, United States
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Building personal cancer vaccines
Patrick Ott
Dana-Farber Cancer Inst., Boston, MA, United States
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Immunopeptidomics: Accelerating the development of personalized cancer immunotherapy
Michal Bassani-Sternberg
CHUV, Ludwig Cancer Research Center, Lausanne, Switzerland
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Insertion-and-deletion-derived tumor-specific neoantigens and the immunogenic phenotype: A pan-cancer analysis
Samra Turajlic
The Royal Marsden NHS Foundation Trust, London, United Kingdom
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NCI-MATCH: A new paradigm in the era of genomic oncology
Alice P. Chen
National Cancer Institute, Bethesda, MD, United States
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The National Lung Matrix Trial (NLMT): Challenges and opportunities
Gary Middleton
University of Birmingham, Birmingham, United Kingdom
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Implementing genomic-driven basket clinical trials
José Baselga
Mem. Sloan Kettering Cancer Ctr., New York, NY, United States
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Transcriptomic analysis of patient-derived xenografts reveals heterogeneity in human and mouse stroma/immune compartments
Henry Qixiang Li
Crown Bioscience, Inc., Beijing, China
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Chromosomal instability as a driver of tumor metastasis
Samuel F Bakhoum
Memorial Sloan Kettering Cancer Center, New York, NY, United States
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Mechanisms of aneuploidy-driven tumorigenesis
Stephen J. Elledge
Harvard Medical School, Boston, MA, United States
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Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures
Thomas G. Graeber
UCLA, Los Angeles, CA, United States
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Structure of the blood-tumor barrier and potential ways to overcome it
Patricia S. Steeg
National Cancer Inst., Bethesda, MD, United States
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Immunotherapy for central nervous system cancers
John H. Sampson
Duke Univ. Medical Ctr., Durham, NC, United States
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Cancer drug distribution in the brain: PET imaging as a tool
E.G. Elisabeth de Vries
Univ. Medical Ctr. Groningen, Groningen, Netherlands
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Systematic elucidation and pharmacologic targeting of mechanistic tumor dependencies
Andrea Califano
Columbia Univ., New York, NY, United States
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Genetics and mechanisms of chemotherapy resistance in acute lymphoblastic leukemia
Adolfo Ferrando
Columbia Univ., New York, NY, United States
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How Ras and Myc cooperate to drive cancers
Gerard I. Evan
University of Cambridge, Cambridge, United Kingdom
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Targeting metabolic vulnerabilities in cancer
Dimitrios Anastasiou
Harvard Medical School, Boston, MA, United States
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Are we ready for metabolic editing yet?
Angela T Alistar
Carol G. Simon Cancer Center, Morristown, NJ, United States
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Targeting the metabolic basis of kidney cancer
W. Marston Linehan
National Cancer Inst., Bethesda, MD, United States