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Immuno-oncology Biomarkers in Clinical Trials
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Introduction
Thomas Frank Gajewski
Univ. of Chicago, Chicago, IL, United States
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First-in-human PET imaging with the PD-L1 antibody 89Zr-atezolizumab
Frederike Bensch
University Medical Center Groningen, Groningen, Netherlands
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Discussant
David A. Mankoff
University of Pennsylvania, Philadelphia, PA, United States
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Intratumor and peripheral Treg modulation as a pharmacodynamic biomarker of the GITR agonist antibody TRX-518 in the first in-human trial
Roberta Zappasodi
Memorial Sloan Kettering Cancer Center, New York, NY, United States
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Discussant
Drew M. Pardoll
Johns Hopkins Kimmel Comp. Cancer Ctr., Baltimore, MD, United States
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Primary results from ZUMA-1: a pivotal trial of axicabtagene ciloleucel (axicel; KTE-C19) in patients with refractory aggressive non-Hodgkin lymphoma (NHL)
Frederick L Locke
H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States
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Immune signatures of cytokine release syndrome and neurologic events in a multicenter registrational trial (ZUMA-1) in subjects with refractory diffuse large B cell lymphoma treated with axicabtagene ciloleucel (KTE-C19)
Frederick L. Locke
H. Lee Moffitt Cancer Center, Tampa, FL, United States
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Discussant
Renier J. Brentjens
Mem. Sloan Kettering Cancer Ctr., New York, NY, United States
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Tumor-associated immune cell PD-L1 expression and peripheral immune profiling: Analyses from CheckMate 141
Robert L. Ferris
University of Pittsburgh Medical Center and University of Pittsburgh Cancer Institute, Pittsburgh, PA, United States
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Evaluation of oral microbiome profiling as a response biomarker in squamous cell carcinoma of the head and neck: Analyses from CheckMate 141
Robert L. Ferris
University of Pittsburgh Medical Center and University of Pittsburgh Cancer Institute, Pittsburgh, PA, United States
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Discussant
Mario Sznol
Yale Cancer Ctr., New Haven, CT, United States