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Molecular diagnostics: Interface with targeted therapeutics clinical trials
Russell R. Broaddus
UT MD Anderson Cancer Center, Houston, TX, United States
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Enrichment and adaptive enrichment designs for clinical trials with targeted therapies
Richard M. Simon
National Cancer Institute, Bethesda, MD, United States
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We learn as we go: Bayesian adaptive designs for efficient and flexible clinical trials
J. Jack Lee
UT MD Anderson Cancer Center, Houston, TX, United States
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Perspectives on trial designs: The past, present, and future of the targeted therapy development
Sumithra J Mandrekar
Mayo Clinic, Rochester, MN, United States
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Introduction
Michael J. Luzzio
Biogen Idec, Inc., Cambridge, MA, United States
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Discovery of a potent covalent mutant-selective EGFR inhibitor: The journey from high throughput screening to EGF816
Gerald Lelais
Genomics Institute of the Novartis Research Institute, San Diego, CA, United States
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Lead optimization through modulation of physicochemical properties: A case study in the discovery of novel CDK9 inhibitors
Yunsong Tong
AbbVie Inc., North Chicago, IL, United States
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Discovery of pan-notch inhibitors as anticancer agents
Ashvinikumar V. Gavai
Bristol-Myers Squibb Co., Princeton, NJ, United States
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“Garbage in” and cancer research
Carolyn Compton
Arizona State University, Scottsdale, AZ, United States
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What a genomicist needs to know about clinical biospecimens
Kenneth Bloom
GE Healthcare, Aliso Viejo, CA, United States
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Human biospecimens for in vitro diagnostics: Regulatory considerations
Yun-Fu Hu
FDA, Silver Spring, MD, United States
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Sample suitability for studies with cancer proteomics
Christopher Kinsinger
National Cancer Institute, Bethesda, MD, United States
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The Impact of Tissue Pre-Analytics on Drug Development
Steven Potts
Flagship Biosciences, Inc., Westminster, CO, United States
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Introduction: New techniques for imaging cancer in the niche
Margaret C. Frame
Univ. of Edinburgh, Edinburgh Cancer Research Centre, Edinburgh, United Kingdom
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Imaging drug-tolerant micro-environments
Erik Sahai
Cancer Research UK, London, United Kingdom
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Imaging immune-tumor interactions
Matthew F Krummel
UCSF, San Francisco, CA, United States
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Long term imaging of the perivascular niche in metastasis and therapy responses
Frank A Winkler
German Cancer Research Ctr., Heidelberg, Germany
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Circulating cell free DNA and cancer
Alain R Thierry
INSERM U896, Montpellier, France
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Circulating miRNAs
Muneesh Tewari
University of Michigan Medical School, Ann Arbor, MI, United States
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Circulating tumor cell biopsies
Caroline Dive
CRUK Manchester Institute, Manchester, United Kingdom
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Malignant stem cells in the circulation
Andreas Trumpp
German Cancer Research Ctr., Heidelberg, Germany
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Introduction
Angelique Whitehurst
UT Southwestern Simmons Comp. Cancer Center, Dallas, TX, United States
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Statistical challenges and opportunities in pharmacogenetics
Alison Motsinger-Reif
North Carolina State University, Raleigh, NC, United States
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Identification of genomic predictors of drug response by high-throuhgput cell line screening
Cyril Benes
Massachusetts General Hospital Cancer Center, Charlestown, MA, United States
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Clinical implications of cancer genome sequencing
Ramaswamy Govindan
Washington Univ. School of Medicine, St, Louis, MO, United States