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From Chemistry to the Clinic: Pathways for Drug Discovery and Development, Part 1: Optimizing Drug Discovery: Insights on an Important Process
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Introduction
Michael J. Luzzio
Biogen Idec, Inc., Cambridge, MA, United States
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Discovery of a potent covalent mutant-selective EGFR inhibitor: The journey from high throughput screening to EGF816
Gerald Lelais
Genomics Institute of the Novartis Research Institute, San Diego, CA, United States
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Lead optimization through modulation of physicochemical properties: A case study in the discovery of novel CDK9 inhibitors
Yunsong Tong
AbbVie Inc., North Chicago, IL, United States
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Discovery of pan-notch inhibitors as anticancer agents
Ashvinikumar V. Gavai
Bristol-Myers Squibb Co., Princeton, NJ, United States