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Opening Remarks
Margaret Foti
American Association for Cancer Research, Philadelphia, PA
President's Remarks
Frank McCormick
UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, United States
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Team Science Award Presentation
The Johns Hopkins Pancreatic Cancer Sequencing Team
Johns Hopkins University School of Medicine, Baltimore, MD, United States
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Award Recipient
Harold L Moses
Vanderbilt-Ingram Cancer Center, Nashville, TN, United States
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Margaret Foti
American Association for Cancer Research, Philadelphia, PA
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Charles L. Sawyers
Memorial Sloan-Kettering Cancer Center, New York, NY, United States
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Marcia R. Cruz-Correa
University of Puerto Rico Comprehensive Cancer Center
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Award Recipient
Robert C Young
RCY Medicine, Philadelphia, PA, United States
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Introduction
Frank McCormick
UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, United States
Award Recipient
Katie Couric
Cancer Advocate, Host of "Katie," and Award-Winning Journalist
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From genes to microenvironments: Cancer as an “organismal” disease
Siddhartha Mukherjee
Columbia University, New York, NY, United States
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Immune checkpoint blockade: Unleashing the immune system against cancer
Suzanne L Topalian
Johns Hopkins Kimmel Comp. Cancer Ctr., Baltimore, MD, United States
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The therapeutic implications of genome sequencing and expression analyses for breast cancer
Charles M Perou
Univ. of North Carolina at Chapel Hill, Chapel Hill, NC, United States
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Wnt signaling, Lgr5 stem cells, and cancer
Hans Clevers
Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences & University Medical Centre Utrecht, Utrecht, Netherlands
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Relationship between tumor biomarkers (BM) and efficacy in EMILIA, a phase III study of trastuzumab emtansine (T-DM1) in HER2-positive metastatic breast cancer (MBC)
José Baselga
Mass. General Hospital Cancer Center Administration, Boston, MA, United States
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Discussant
Gordon B Mills
UT MD Anderson Cancer Ctr., Houston, TX, United States
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Results of two phase I multicenter trials of AZD5363, an inhibitor of AKT1, 2 and 3: Biomarker and early clinical evaluation in Western and Japanese patients with advanced solid tumors
Udai Banerji
Inst. of Cancer Research, Sutton, United Kingdom
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Discussant
Carlos L Arteaga
Vanderbilt-Ingram Cancer Ctr., Nashville, TN, United States
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Towards defining the genetic framework for clinical response to treatment with BYL719, a PI3Kalpha-specific inhibitor
Jordi Rodon
Department of Medical Oncology, Vall d'Hebron University Hospital, Barcelona, Spain
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Discussant
Lewis C. Cantley
Weill Cornell Medical College, New York, NY, United States
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GDC-0032, a beta isoform-sparing PI3K inhibitor: Results of a first-in-human phase Ia dose escalation study
Dejan Juric
Massachusetts General Hospital Cancer Center, Boston, MA, United States
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Discussant
Sarat Chandarlapaty
Mem. Sloan-Kettering Cancer Ctr., New York, NY, United States
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REGARD: A phase III, randomized, double-blind trial of ramucirumab and best supportive care (BSC) versus placebo and BSC in the treatment of metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma following disease progression on first-line platinum- and/or fluoropyrimidine-containing combination therapy
Charles S Fuchs
Dana-Farber Cancer Inst., Boston, MA, United States
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Discussant
Herbert I Hurwitz
Duke Univ. Medical Ctr., Durham, NC, United States
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Margaret Foti, Ph.D., M.D. (h.c.)
Chief executive officer, American Association for Cancer Research
Kyle MacLachlan
SU2C Celebrity Ambassador
Phillip Sharp, Ph.D.
SU2C Scientific Advisory Committee chairperson, institute professor David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
William G. Nelson, M.D., Ph.D.
SU2C Scientific Advisory Committee vice-chairperson; director, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University
Kathleen Ruddy
Chief executive officer, St. Baldrick's Foundation
John M. Maris, M.D.
Director, the Center for Childhood Cancer Research, The Children’s Hospital of Philadelphia
Crystal L. Mackall, M.D.
Chief, Pediatric Oncology Branch, National Cancer Institute
Kari and Tom Whitehead
Parents of Emily Whitehead
Emily Whitehead
Cancer patient
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Cancer genetic and epigenetic interactions
Peter W Laird
USC Epigenome Center, Los Angeles, CA, United States
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TET proteins and altered DNA methylation in cancer
Anjana Rao
La Jolla Inst. for Allergy & Immunology, La Jolla, CA, United States