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State of the art in proteomics technologies
Daniel C. Liebler
Vanderbilt University, Nashville, TN, United States
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Leveraging the synergy between genomics and proteomics through bioinformatics
Bing Zhang
Vanderbilt University School of Medicine, Nashville, TN, United States
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Proteogenomic analysis of colon tumors and cell lines
Robbert J.C. Slebos
Vanderbilt University, Nashville, TN, United States
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Dissecting signaling pathways in cancer using proteomics
Akhilesh Pandey
Johns Hopkins Univ., Baltimore, MD, United States
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Introduction
Guowei Fang
AbbVie, Inc., North Chicago, IL, United States
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Chemical probes for epigenetic proteins
Paul Brennan
University of Oxford, Oxford, United Kingdom
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Discovering chemical probes of histone methyltransferases
H. Ümit Kaniskan
Icahn School of Medicine at Mt. Sinai, New York, NY, United States
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Discovery of EPZ015666: A first-In-class PRMT5 inhibitor with potent in vitroand in vivo activity
Kenneth W. Duncan
Epizyme, Inc., Cambridge, MA, United States
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Introduction
Donald Ogilvie
Cancer Research UK Manchester Institute, Manchester, United Kingdom
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Chemical biology approaches to target validation in cancer
Julian Blagg
Inst. of Cancer Research, Sutton, Surrey, United Kingdom
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Collaborating with industry to find chemical hits versus difficult targets
Allan M. Jordan
Cancer Research UK Manchester Inst., Manchester, United Kingdom
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Reducing the PAIN in academic drug discovery
Jonathan B Baell
Monash University, Parkville, Australia
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Partnering with academia in early drug discovery: An industry perspective
Dashyant Dhanak
Janssen Research Development, LLC, Spring House, PA, United States
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Optimization of glutaminase inhibitors for the treatment of cancer
Rene M. Lemieux
Agios Pharmaceuticals, Cambridge, MA, United States
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Discovery of in vivo inhibitors of Lactate Dehydrogenase A (LDHA)
Hans Purkey
Genentech, Inc., South San Francisco, CA, United States
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Discovery of a Potent, Selective, NAMPT inhibitor from the Pyridyloxyacetyl-Dihydro-Isoquinoline-Sulfonamide series that demonstrated robust efficacy and improved tolerability with nicotinic acid co-administration
Timothy P. Burkholder
Eli Lilly and Company, Indianapolis, IN, United States
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MCT1: The journey from phenotypic screen hit to clinical candidate
Jon Winter
AstraZeneca R&D, Cheshire, United Kingdom
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Untargeted metabolomics: Technologies to study cancer metabolism at the global scale
Gary Patti
Washington University in St. Louis, St. Louis, MO, United States
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Understanding metabolic heterogeneity in cancer cells and human tumors
Ralph J. DeBerardinis
UT Southwestern Medical Center, Dallas, TX, United States
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Similarity and diversity in cancer cell metabolism
Dennis Vitkup
Columbia University, New York, NY, United States
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Integrating metabolomics with transcriptional profiling: Statistical aspects of hypothesis generating systems data analysis
Edward Driggers
General Metabolics, Winchester, MA, United States
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Non-immunogenic PET reporter imaging of HSC transplants and T cell immunotherapies
Owen N. Witte
UCLA, Los Angeles, CA, United States
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Fluorine-19 MRI cell tracking for immune cell detection and quantification in vivo
Eric T. Ahrens
USCD, La Jolla, CA, United States
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Visualising immune responses in cancer patients
Jolanda de Vries
Nijmegen Centre for Molecular Life Sciences, Nijmegen, Netherlands
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PT2385: First-in-class HIF-2α antagonist for the treatment of renal cell carcinoma
Eli M. Wallace
Peloton Therapeutics, Inc., Dallas, TX, United States