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Biomarkers of systemic inflammation associated to reduced clinical activity of atezolizumab monotherapy in patients with metastatic triple negative breast cancer
Luciana Molinero
Genentech, South San Francisco, CA, United States
- Permission not
granted for presentation
A strong HPV-specific T-cell response after chemo-immunotherapy for advanced cervical cancer is associated with prolonged survival
Cornelis J M Melief
Leiden Univ. Medical Ctr. & ISA Pharmaceuticals BV, Leiden, Netherlands
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Analysis of immune cell infiltrates as predictors of response to the checkpoint inhibitor pembrolizumab in the neoadjuvant I-SPY 2 TRIAL
Michael J Campbell
UCSF, San Francisco, CA, United States
- Free
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A Phase Ib study of CD40 agonistic monoclonal antibody APX005M together with gemcitabine (Gem) and nab-paclitaxel (NP) with or without nivolumab (Nivo) in untreated metastatic ductal pancreatic adenocarcinoma (PDAC) patients
Mark H O'Hara
Abramson Cancer Center of the University of Pennsylvania, Philadelphia, PA, United States
- Free
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Discussant
Aung Naing
UT MD Anderson Cancer Ctr., Houston, TX, United States
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Preliminary efficacy and safety results of savolitinib treating patients with pulmonary sarcomatoid carcinoma (PSC) and other types of non-small cell lung cancer (NSCLC) harboring MET exon 14 skipping mutations
Shun Lu
Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China
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TATTON Phase Ib expansion cohort: Osimertinib plus savolitinib for patients (pts) with EGFR-mutant, MET-amplified NSCLC after progression on prior epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI)
Lecia Sequist
Massachusetts General Hospital, Boston, MA, United States
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Osimertinib plus selumetinib for patients (pts) with EGFR-mutant (EGFRm) NSCLC following disease progression on an EGFR-TKI: Results from the Phase Ib TATTON study
Suresh S Ramalingam
Emory Univ. Winship Cancer Inst., Atlanta, GA, United States
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Discussant
Roy S Herbst
Yale Cancer Ctr., New Haven, CT, United States
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Turning the heat up on pancreatic cancer: Lessons on overcoming a “cold” immunologic microenvironment
Elizabeth M Jaffee
Johns Hopkins Sidney Kimmel Comp. Cancer Ctr., Baltimore, MD, United States
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Introduction
Nilofer S Azad
Johns Hopkins Sidney Kimmel Comp. Cancer Ctr., Baltimore, MD, United States
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Efficacy and safety of entinostat (ENT) and pembrolizumab (PEMBRO) in patients with melanoma previously treated with anti-PD1 therapy
Ryan J. Sullivan
Massachusetts General Hospital, Boston, MA, United States
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Discussant
Stephen B Baylin
Johns Hopkins Univ. School of Medicine, Baltimore, MD, United States
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Tumor mutational burden (TMB) as a biomarker of survival in metastatic non-small cell lung cancer (mNSCLC): Blood and tissue TMB analysis from MYSTIC, a Phase III study of first-line durvalumab ± tremelimumab vs chemotherapy
Solange Peters
Centre Hospitalier Universitaire Vaudois, Lausanne University, Lausanne, Switzerland
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Discussant
David R Gandara
UC Davis Comprehensive Cancer Ctr., Sacramento, CA, United States
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Phase I evaluation of M7824, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with human papillomavirus (HPV)-associated malignancies
Julius Strauss
Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States
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Discussant
Maura L Gillison
UT MD Anderson Cancer Ctr., Houston, TX, United States
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Pembrolizumab after two or more lines of prior therapy in patients with advanced small-cell lung cancer (SCLC): Results from the KEYNOTE-028 and KEYNOTE-158 studies
Hyun Cheol Chung
Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea, Republic of
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Discussant
Taofeek Kunle Owonikoko
Emory University, Atlanta, GA, United States
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From discovery to clinics: Design considerations in biomarker studies
Yingye Zheng
Fred Hutchinson Cancer Research Ctr., Seattle, WA, United States
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Needle in a haystack: Biomarker discovery in high-dimensional data
Shilin Zhao
Vanderbilt University Medical Center, Nashville, TN, United States
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Precision oncology: Integrating biomarkers in phase III clinical trial designs
Antje Hoering
Cancer Research and Biostatistics, Seattle, WA, United States
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Population risk stratification: Integrating biomarkers in cancer risk assessment
Ruth Pfeiffer
NCI-DCEG, Bethesda, MD, United States
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Clinical experience with radiotherapy in the context of immune checkpoint blockade
Michael A. Postow
Memorial Sloan Kettering Cancer Center, New York, NY, United States
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- Some slides withheld
Effects of radiation on tumor antigenicity and adjuvanticity: From mouse to human
Sandra Demaria
Weill Cornell Medical College, New York, NY, United States