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From discovery to clinics: Design considerations in biomarker studies
Yingye Zheng
Fred Hutchinson Cancer Research Ctr., Seattle, WA, United States
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Needle in a haystack: Biomarker discovery in high-dimensional data
Shilin Zhao
Vanderbilt University Medical Center, Nashville, TN, United States
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Precision oncology: Integrating biomarkers in phase III clinical trial designs
Antje Hoering
Cancer Research and Biostatistics, Seattle, WA, United States
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Population risk stratification: Integrating biomarkers in cancer risk assessment
Ruth Pfeiffer
NCI-DCEG, Bethesda, MD, United States
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Discovery of BLU-667 for RET driven cancers
Jason Brubaker
Blueprint Medicines, Cambridge, MA, United States
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Discovery and development of USP7 inhibitors
Tim Harrison
Almac Discovery, Belfast, Ireland
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Identification and optimization of chemical series that lead to discovery of erdafitinib: A potent pan-fibroblast growth factor receptor (FGFR) inhibitor
Patrick Angibaud
Janssen R & D, Val-de-Reuil, France
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Development of potent and selective CD73 inhibitors: Discovery and characterization of AB680
Jenna Jeffrey
Arcus Biosciences, Inc., Hayward, CA, United States
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How to develop trial objectives: Translation of science from bench to bedside to bench
Patricia M LoRusso
Yale Cancer Center, New Haven, CT, United States
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Modernizing eligibility criteria for oncology clinical trials
Tatiana Prowell
U.S. Food and Drug Administration and Johns Hopkins Kimmel Cancer Center, Silver Spring, MD, United States
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Biostatistical principals of clinical trial design
Mithat Gonen
Mem. Sloan Kettering Cancer Ctr., New York, NY, United States
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Designing meaningful and impactful clinical trials
Jyoti D Patel
Univ. of Chicago Medical Ctr., Chicago, IL, United States
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The changing landscape of oncology drug development
David S Hong
UT MD Anderson Cancer Ctr., Houston, TX, United States
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GO/NO GO decisions in cancer drug discovery: Has the decision making process evolved?
Nancy E. Kohl
Consultant, Wellesley, MA, United States
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Insights from a clinical development prediction algorithm: What we measure matters
David Feltquate
Bristol-Myers Squibb, New York, NY, United States
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Pivotal decision making in oncology drug development: A perspective
Sandra J. Horning
Genentech, Inc., San Francisco, CA, United States
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Is there a place for traditional phase 2 trials in cancer drug development?
Michael A. Carducci
Johns Hopkins Kimmel Comp. Cancer Ctr., Baltimore, MD, United States
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The promises and challenges of master protocols: Basket and umbrella trials and beyond
Marc Theoret
U.S. Food and Drug Administration, Silver Spring, MD, United States
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Meaningful biostatistical outcomes of expansion cohort trials
Alexia Iasonos
Memorial Sloan Kettering Cancer Center, New Y ork, NY, United States
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The multi-trial platform design: When and how?
Lorenzo Trippa
Dana-Farber Cancer Institute, Boston, MA, United States
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Improving nerve tissue preservation using fluorescence guided surgery for improved clinical outcomes
Summer L Gibbs
Oregon Health & Science University, Portland, OR, United States
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Microdose clinical trials update with fluorescent anti-EGFR Affibody ABY-029
Brian W Pogue
Dartmouth College, Hanover, NH, United States
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Optical and optoacoustic imaging: a hyperloop mechanism for drug development and optical tracer evaluation
Gooitzen M van Dam
University Medical Center Groningen, Groningen, Netherlands
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Optical surgical navigation using fluorescently labeled antibodies during head and neck cancer resection
Jason M. Warram
University of Alabama at Birmingham, Birmingham, AL, United States
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Introduction
Richard M. Marais
Cancer Research UK Manchester Inst., Manchester, United Kingdom