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Somatic alterations in human cancer genomes
              Matthew L. Meyerson
              Dana-Farber Cancer Inst., Boston, MA, United States
      
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Challenges and opportunities for genomic medicine
              P. Andrew Futreal
              UT MD Anderson Cancer Ctr., Houston, TX, United States
      
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Advances and future of finding cancer associated genes
              Gad Getz
              Broad Inst. of MIT and Harvard, Cambridge, MA, United States
      
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BRAF and RAS signaling in melanoma: From basic biology to clinical exploitation
              Richard M. Marais
              Cancer Research UK Manchester Institute, Manchester, United Kingdom
      
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Title to be announced
              Neal Rosen
              Mem. Sloan-Kettering Cancer Ctr., New York, NY, United States
      
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Matrix-dependent adaptive resistance to targeted therapy
              Joan S. Brugge
              Harvard Medical School, Boston, MA, United States
      
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Welcome and Opening Remarks
              Jeffrey A. Engelman
              Massachusetts General Hospital, Charlestown, MA, United States
      
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Wnt signaling, Lgr5 stem cells, and cancer
              Hans Clevers
              Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences & University Medical Centre, Utrecht, Netherlands
      
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Targeting the PD-1 pathway: Resetting the balance between the immune system and cancer
              Suzanne L. Topalian
              Johns Hopkins Kimmel Comp. Cancer Ctr., Baltimore, MD, United States
      
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Using synthetic lethality to find effective combination therapies for cancer
              René Bernards
              Netherlands Cancer Inst., Amsterdam, Netherlands
      
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Mechanisms of resistance to RAF/MEK inhibitors
              David B. Solit
              Mem. Sloan-Kettering Cancer Ctr., New York, NY, United States
      
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Overcoming acquired resistance to first-generation kinase inhibitors in lung cancer
              William Pao
              Vanderbilt Univ., Nashville, TN, United States
      
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Mechanisms of acquired resistance to ALK/ROS1 inhibitors
              Alice T. Shaw
              Massachusetts General Hosp. Cancer Ctr., Boston, MA, United States
      
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The metabolic phase of the cell cycle
              Eyal Gottlieb
              Cancer Research UK, Beatson Institute, Glasgow, United Kingdom
      
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The genetic basis of kidney cancer: A metabolic disease
              W. Marston Linehan
              National Cancer Inst., Bethesda, MD, United States
      
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Ras-induced macropinocytosis: Metabolic adaptation to signaling in the absence of adequate nutrients
              Craig B. Thompson
              Mem. Sloan-Kettering Cancer Ctr., New York, NY, United States
      
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IDH mutations and tumorigenicity
              Katharine E. Yen
              Agios Pharmaceuticals, Cambridge, MA, United States
      
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Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange
              Michael Burns
              Vanderbilt University School of Medicine, Nashville, TN, United States
      
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LEE011: An orally bioavailable, selective small molecule inhibitor of CDK4/6-- Reactivating Rb in cancer
              Sunkyu Kim
              Novartis Institutes for Biomedical Research, Cambridge, MA, United States
      
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Selective sensitization of mutant K-Ras cancer cells to DNA damage based therapies by targeting wild type H- and N-Ras
              Elda Grabocka
              NYU Langone Medical Center, New York, NY, United States
      
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BRAF fusions define a distinct molecular subset of melanomas with potential sensitivity to MEK inhibition
              Katherine Hutchinson
              Vanderbilt University, Nashville, TN, United States
      
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Working together to identify new epigenetic targets for cancer
              Chas Bountra
              University of Oxford, Oxford, United Kingdom
      
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Targeting enhancers in cancers
              James E. Bradner
              Dana-Farber Cancer Inst., Boston, MA, United States
      
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Designing p300/CBP histone acetyltransferase inhibitors for cancer
              Philip A. Cole
              Johns Hopkins Univ. School of Medicine, Baltimore, MD, United States
      
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Protein methyltransferase inhibitors as personalized cancer therapeutics
              Robert A. Copeland
              Epizyme, Inc., Cambridge, MA, United States
      
