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Clinical Trial Paradigms in the Era of Novel Therapies
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New paradigms for early-phase clinical trials
James H. Doroshow
National Cancer Institute, Bethesda, MD, United States
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Phasing out phase III trials: How much evidence do we need if the target is clearly hit?
Jaap Verweij
Erasmus University Medical Center - Daniel den Hoed Cancer Center, Rotterdam, Netherlands
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Development of clinical trials incorporating genomic signatures: Lessons learned
Lisa M McShane
National Cancer Institute, Bethesda, MD, United States
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Clinical trial designs for targeted therapies
John J. Crowley
Cancer Research and Biostatistics, Seattle, WA, United States