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Spotlight on Proffered Papers Session 1
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Characterization of antitumor activity of TAS6417, a novel EGFR-TKI targeting exon 20 insertions
Shinichi Hasako
TAIHO PHARMACEUTICAL CO., LTD., Tsukuba, Japan
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EGFR-CD3 bispecific Probody™ therapeutic induces tumor regressions and increases maximum tolerated dose >60-fold in preclinical studies
Leila M Boustany
CytomX Therapeutics, South San Francisco, CA, United States
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Neratinib has clinical activity in HER2-amplified breast cancer patients with tumors that have acquired activating mutations in HER2
Maurizio Scaltriti
Memorial Sloan-Kettering Cancer Center, New York, NY, United States
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granted for presentation
Loss of the lysosomal transporter SLC46A3 is a mechanism for innate and acquired resistance to non-cleavable maytansine and pyrrolobenzodiazepine-based antibody-drug conjugates
Krista Kinneer
MedImmune, Gaithersburg, MD, United States
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for presentation
AG-120 (ivosidenib), a first-in-class mutant IDH1 inhibitor, promotes morphologic changes and upregulates liver-specific genes in IDH1 mutant cholangiocarcinoma
Vikram Deshpande
Massachusetts General Hospital, Boston, MA, United States
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Phase 1 study of the EZH2 inhibitor, tazemetostat, in children with relapsed or refractory INI1-negative tumors including rhabdoid tumors, epithelioid sarcoma, chordoma, and synovial sarcoma
Susan Chi
Dana-Farber Cancer Institute, Boston, MA, United States
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First in human, dose escalation trial of the combination of dabrafenib, trametinib, and navitoclax in patients with BRAF mutant solid tumors
Ryan J Sullivan
Harvard Medical School/MGH, Boston, MA, United States
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Preliminary results from a phase 2 proof of concept trial of tipifarnib in tumors with HRAS mutations
Alan Ho
Memorial Sloan Kettering Cancer Center, New York, NY, United States
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Durable responses observed in recurrent high-grade glioma (rHGG) with Toca 511 and Toca FC treatment
Clark C Chen
University of Minnesota, Minneapolis, MN, United States