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Designing Biomarker Studies to Achieve Desired Clinical Applications
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Intended clinical application drives your study design: Principles and operational considerations
Ziding Feng
Fred Hutchinson Cancer Research Ctr., Seattle, WA, United States
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Evaluating biomarkers for prognostic enrichment of clinical trials
Kathleen Kerr
University of Washington, Seattle, WA, United States
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Deriving early detection biomarker performance goals by setting a minimum benefit-to-harm ratio
Steven J Skates
Massachusetts General Hospital, Boston, MA, United States